Author:
Edition: 1
Publisher: Marcel Dekker Inc
Binding: Hardcover
ISBN: 082478880X
Monoclonal Antibodies and Peptide Therapy in Autoimmune Diseases (Immunology Series)
Combining principles of modern immunology with applications to immunopathology, this reference documents developments in the immunotherapy of autoimmune diseases - emphasizing monoclonal antibody and peptide approaches. Medical books Monoclonal Antibodies and Peptide Therapy in Autoimmune Diseases . Detailing possible antigen-specific manoeuvres, from targeting the T-cell receptor itself to intervening at the level of the major histocompatibility complex (MHC) antigens, "Monoclonal Antibodies and Peptide Therapy in Autoimmune Diseases": provides an update on T-cell basic science; discusses most monoclonal antibodies used in autoimmune disease experiments; describes the concept of peptide therapy in its various forms; and presents fundamental pharmacological data that clarify the clinical usage of these new agents Medical books Genetex - GTX61466 - CD86 antibody [EP1158Y], N-term, GeneTex (Each. B7-2 (CD86) is an important costimulatory molecule for the priming and activation of naive and memory T cells, respectively. Soluble CD86 is produced by resting monocytes and results from an alternatively spliced transcript (CD86deltaTM) characterized by deletion of the transmembrane domain . Engagement of CD28 with B7-1 and B7-2 ligands on antigen-presenting cells (APCs) provides a stimulatory signal for T-cell activation, whereas subsequent engagement of CTLA-4 with these same ligands results in attenuation of the response. Given their central function in immune modulation, CTLA-4- and CD28-associated signaling pathways are primary therapeutic targets for preventing autoimmune disease, graft versus host disease, graft rejection and promoting tumor immunity . It has also been shown that on B cells and macrophages, heat shock proteins GroES and GroEL both stimulated the expression of B7-2 This listing is for Each (100 l) Species Reactivity Human, Mouse, Rat MW (kDa) 70 Host Rabbit Clone EP1158Y Isotype IgG Unit Each (100 l) Application Note Recommended Starting Dilutions: For WB: Use at a dilution of 1:500 For IHC: Use at a dilution of 1:100 - 250 For ICC: Use at a dilution of 1:100 - 250 For FACS: Use at a dilution of 1:10 For IP: Use at a dilution of 1:50 Optimal working dilution for a specific application should be determined by the investigator. Immunogen A synthetic peptide corresponding to residues near the N-terminus of human CD86 was used as an immunogen. Monoclonal/Polyclonal Monoclonal Purification Cell Supernatant Storage Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Storage Instruction Store at -20 C. Stable for 12 months from date of receipt. Tested Applications FACS, ICC/IF, IHC-P, IP, WB
Download link for Genetex - GTX85069 - IL-32 antibody, GeneTex (Each (100μG))
B7-2 (CD86) is an important costimulatory molecule for the priming and activation of naive and memory T cells, respectively. Soluble CD86 is produced by resting monocytes and results from an alternatively spliced transcript (CD86deltaTM) characterized by deletion of the transmembrane domain . Engagement of CD28 with B7-1 and B7-2 ligands on antigen-presenting cells (APCs) provides a stimulatory signal for T-cell activation, whereas subsequent engagement of CTLA-4 with these same ligands results in attenuation of the response. Given their central function in immune modulation, CTLA-4- and CD28-
Medical Book Monoclonal Antibodies and Peptide Therapy in Autoimmune Diseases
Detailing possible antigen-specific manoeuvres, from targeting the T-cell receptor itself to intervening at the level of the major histocompatibility complex (MHC) antigens, "Monoclonal Antibodies and Peptide Therapy in Autoimmune Diseases": provides an update on T-cell basic science; discusses most monoclonal antibodies used in autoimmune disease experiments; describes the concept of peptide therapy in its various forms; and presents fundamental pharmacological data that clarify the clinical usage of these new agents. Containing over 1100 literature citations, "Monoclonal Antibodies and Peptide Therapy in Autoimmune Diseases" should be a useful resource for immunologists, rheumatologists, pharmacologists, pathologists, dermatologists, nephrologists, and graduate and medical school students in these disciplines.
